1-(4-fluorophenyl)-5-iodo-1H-indazole → (2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenyl-butan-2-amine

HRID 13080Notes

Reaction equation

HRID 13080 reaction equation
[Cl-].[OH:2][C@H:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C@@H:4]([NH3+:6])[CH3:5].[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26](I)=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26]([O:2][C@H:3]([CH2:7][C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)[C@@H:4]([NH2:6])[CH3:5])=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazoleHCID 66812618(2S,3R)-3-hydroxy-4-phenylbutan-2-aminium chloride

Product 1

HCID 59339878(2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenyl-butan-2-amine

Procedure

Prepared as described in Example 1 from (2S,3R)-3-hydroxy-4-phenylbutan-2-aminium chloride (290 mg, 1.44 mmol) and 1-(4-fluorophenyl)-5-iodoindazole (583 mg, 1.73 mmol). Yield 340 mg (63%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3afe8bce878f4910be15ba760af37f7c
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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