Potassium Carbonate → [4-(5-Carbamoylpyrazin-2-yloxy)benzyl]phenethylcarbamic acid tert-butyl ester

HRID 130826노트

반응식

HRID 130826 반응식
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([NH2:10])=[O:9])=[N:6][CH:7]=1.[C:11]([O:15][C:16](=[O:34])[N:17]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH3:14])([CH3:13])[CH3:12].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[C:11]([O:15][C:16](=[O:34])[N:17]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][C:2]2[CH:7]=[N:6][C:5]([C:8](=[O:9])[NH2:10])=[CH:4][N:3]=2)=[CH:29][CH:28]=1)[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1814505-ChloropyrazinamideHCID 59729945(4-Hydroxybenzyl)phenethylcarbamic acid tert-butyl ester

생성물 1

HCID 59730363[4-(5-Carbamoylpyrazin-2-yloxy)benzyl]phenethylcarbamic acid tert-butyl ester수율 12.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
140 °C

실험 절차

Take up 5-chloropyrazine-2-carboxamide (0.0527 g, 0.334 mmol), (4-hydroxybenzyl)phenethylcarbamic acid tert-butyl ester (Example 380, Part B) (0.110 g, 0.334 mmol) and K2CO3 (0.116 g, 0.836 mmol) in DMF (0.80 mL). Heat at 140° C. for 21.5 hours. Concentrate the reaction mixture then purify by flash chromatography, eluting with 50% ethyl acetate in hexanes to give the title compound (0.019 g, 12.7%): MS ES+ 448.8 (M+H)+, base peak MS ES+ 392.8 (M−C(CH3)3)+; HPLC [YMC-Pack Pro C-18 (150×4.6 mm, S-5 microm), 0.1% TFA/acetonitrile in 0.1% TFA/water at 1.0 mL/min, 30-99% over 19 min], tR=14.8 min, 100% purity.

후처리

  1. concentrationConcentrate the reaction mixture
  2. customthen purify by flash chromatography
  3. washeluting with 50% ethyl acetate in hexanes

출처 및 근거

ORD 기록
ord-0e23cf580caa493aa1160f52542796ad
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381719B2

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