HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 5-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-[1,3]dioxolan-2-ylphenol | HCID 11321164 | — |
| Reactant | 5-Fluoropyridine-2-carboxamide | HCID 21904754 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(4-[1,3]Dioxolan-2-ylphenoxy)pyridine-2-carboxamide | HCID 68749528 | — |
Reaction Steps
Dissolve 4-[1,3]dioxolan-2-ylphenol (Part C2, 0.471 g, 2.85 mmol) in DMF (89.5 mL). Add NaH (80% in mineral oil) (0.128 g, 4.28 mmol). Stir at room temperature for about an hour before adding 5-fluoropyridine-2-carboxamide (0.400 g, 2.85 mmol). Heat at 80° C. for 4.5 hours before concentrating to dryness to form 5-(4-[1,3]dioxolan-2-ylphenoxy)pyridine-2-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07381719B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-a3e46bba254348b2973c86384e1449e7 |
| Source note | uspto-grants-2008_06 |