HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1309078Generated: November 3, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1309078
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Catalyst | copper(I) bromide | HCID 24593 | — |
| Catalyst | (S)-N,N'-Dimethyl-1,1'-binaphthyldiamine | HCID 628556 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 7.91% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 0% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-c1dc502f36764e10b2ec164318032893 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
