HuagongsheHuagongshe Chemistry Print Report · For research reference only
(tert-Butylamino)(oxo)acetic acid → N-[(1R,2S)-1-[1-(4-Fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N'-tert-butyl-oxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (tert-Butylamino)(oxo)acetic acid | HCID 5187990 | — |
| Reactant | (1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine | HCID 59339733 | — |
| Product | N-[(1R,2S)-1-[1-(4-Fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N'-tert-butyl-oxamide | HCID 25013007 | — |
Reaction Steps
Prepared as described in Example 76 using (1R,2S)-1-[1-(4-fluorophenyl)-indazol-5-yl]oxy-1-(3-methoxyphenyl)-propan-2-amine (51 mg, 0.13 mmol) and 2-(tert-butylamino)-2-oxoacetic acid (19 mg, 0.13 mmol). Yield 53 mg (78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07728030B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-71fc53c91b064425ba31d21d4b80c591 |
| Source note | uspto-grants-2010_06 |