Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 6-(2-Fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Fluoro-4-hydroxy-5-methoxybenzaldehyde | HCID 598452 | — |
| 반응물 | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| 생성물 | 6-(2-Fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile | HCID 85957486 | 66.9% |
반응 단계
Using a method similar to Example 710, Step 2, using 3-fluoro-4-hydroxy-5-methoxy-benzaldehyde (Journal of Organic Chemistry (1986), 51(21), 4072-3.) (2.84 g, 16.7 mmol), 6-chloronicotinonitrile (2.31 g, 16.7 mmol) and K2CO3 (3.46 g, 25.0 mmol) gives 6-(2-fluoro-4-formyl-6-methoxy-phenoxy)-nicotinonitrile (3.04 g) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381719B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-0261f9499a0f4caea1b2225bd90faa9d |
| 출처 메모 | uspto-grants-2008_06 |