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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1310421Generated: October 29, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1310421

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentCID 21226062HCID 21226062—
Catalyst1,3-Bis(2,4,6-trimethylphenyl)imidazolium chlorideHCID 2734211—
CatalystHCID 178425458HCID 178425458—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-9a299155c77d49a9b70e60868a437011
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions