Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Ethyl 3-aminopropanoate | HCID 419889 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 59731134 | HCID 59731134 | 67.1% |
Reaction Steps
459 mg of 4-fluoronitrobenzene, 500 mg of β-alanine ethyl ester and 1.15 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone (NMP). The reaction medium was heated at 70° C. for 8 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 520 mg of ethyl 3-(4-nitrophenylamino)propionate (6) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07384432B2 |
|---|
| Source dataset | uspto-grants-2008_06 |
|---|
| ORD ID | ord-7e66443c3c9e4676ac28b1b1f366b9d2 |
|---|
| Source note | uspto-grants-2008_06 |
|---|
