Triethylamine → Ethyl 2-(4-nitrophenylamino)-3-methylbutyrate

Participants

Reaction Conditions

Reaction Steps

162 mg of 4-fluoronitrobenzene, 200 mg of L-valine ethyl ester and 0.4 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone (NMP). The reaction medium was heated at 70° C. for 8 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 100 mg of ethyl 2-(4-nitrophenylamino)-3-methylbutyrate (8) were obtained.

Provenance & Evidence