(1R,2S)-2-amino-1-phenylpentan-1-ol hydrochloride → (1R,2S)-2-amino-1-(3-methoxyphenyl)pentan-1-ol hydrochloride

HRID 13108Notes

Reaction equation

HRID 13108 reaction equation
[ClH:1].N[C@@H](CCC)[C@@H](C1C=CC=CC=1)O.[CH3:15][O:16][C:17]1[CH:18]=[C:19]([C:23](=[O:36])[C@@H:24]([NH:28]C(=O)OC(C)(C)C)[CH2:25][CH2:26][CH3:27])[CH:20]=[CH:21][CH:22]=1>>[ClH:1].[NH2:28][C@@H:24]([CH2:25][CH2:26][CH3:27])[C@@H:23]([C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([O:16][CH3:15])[CH:18]=1)[OH:36]

Participants

3

Reactant 2

HCID 12843463(1R,2S)-2-amino-1-phenylpentan-1-ol hydrochlorideHCID 59339638(S)-tert-butyl 1-(3-methoxyphenyl)-1-oxopentan-2-ylcarbamate

Product 1

HCID 66812884(1R,2S)-2-amino-1-(3-methoxyphenyl)pentan-1-ol hydrochloride

Procedure

was synthesised in the same way as 91b from (S)-tert-butyl 1-(3-methoxyphenyl)-1-oxopentan-2-ylcarbamate (213 mg, 0.693 mmol).

Sources & evidence

ORD record
ord-cb47dfaf7be64ced834bd4bb1ae1f40b
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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