Diisopropylethylamine → 6-[(2-{[6-(2,4-Dichlorophenyl)-5-nitropyrazin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(2,4-dichlorophenyl)-5-bromo-2-nitropyrazine (20 mg, 0.057 mmol) in DMF (1 ml), 6-[(2-aminoethyl)amino]pyridine-3-carbonitrile (10.0 mg, 0.06 mmol) and diisopropylethyl amine (40 μl, 0.228 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (5% methanol in methylene chloride) to afford the title compound as bright yellow solid.

Provenance & Evidence