Bromine → HCID 21864961, compound

HRID 131154Notes

Reaction equation

HRID 131154 reaction equation
[C:1]([C:4]1[C:9]([CH2:10][CH3:11])=[N:8][CH:7]=[CH:6][N:5]=1)(=[O:3])[CH3:2].[Br:12]Br>C(Cl)(Cl)Cl>[Br:12][CH2:2][C:1]([C:4]1[C:9]([CH2:10][CH3:11])=[N:8][CH:7]=[CH:6][N:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 24408BromineHCID 619181-(3-Ethylpyrazinyl)ethan-1-one

Product 1

HCID 21864961HCID 21864961, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of 2-acetyl-3-ethylpyrazine (1.0 g, 6.66 mmol) in chloroform (15 mL) was added Br2 (0.38 mL, 7.32 mmol, 1.1 eq) dropwise at 0° C. The reaction mixture was stirred at 40° C. for 4 h. The reddish solution turned to dark brown. The reaction mixture was concentrated in vacuo and used in the step 2 without further purification. MS LC-MS (MH+=231)

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customused in the step 2 without further purification

Sources & evidence

ORD record
ord-6591e350857b488194b5181424d92381
Source dataset
uspto-grants-2008_06
Patent number
US07384947B2

Reaction notes

Loading…