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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1311739Generated: October 30, 2026

Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

https://huagongshe.com/reaction/1311739

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
ReactantBenzene, 1-iodo-4-(trifluoromethyl)-HCID 67993—
ReagentCID 21226062HCID 21226062—
Catalyst(1S,2S)-(-)-1,2-Diaminocyclohexane-N,N'-bis(2'-diphenylphosphinobenzoyl)HCID 10963521—
CatalystHCID 178426894HCID 178426894—
SolventDimethyl SulfoxideHCID 679—
ProductCaffeineHCID 2519—
Product4-(4-Trifluoromethylphenyl)morpholineHCID 109333100%
Product4-(3-(Trifluoromethyl)phenyl)morpholineHCID 154202990%

Reaction Conditions

Temperature30 °C

Provenance & Evidence

DOI10.1021/jacs.6c05959
Source datasetHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
ORD IDord-ac99dd54bf654aaeb25cac97afca3d3b
Source noteHigh-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions