Ethanolamine → HCID 10268808, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 7-bromo-2-chloro-4-(2-furyl)thieno[3,2-d]pyrimidine (110 mg, 0.35 mmol) in 1-methyl-2-pyrrolidinone (1 mL) was treated with ethanolamine (32 μL, 0.52 mmol), heated at 90° C. for 16 h, cooled, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo and purified by chromatography (SiO2: EtOAc:Heptane, 1:1) to give the title compound (45 mg, 38%) as a yellow solid.

Provenance & Evidence