HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 59732370, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 4-(Furan-2-yl)thieno(3,2-d)pyrimidin-2-amine | HCID 9964493 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 59732370 | HCID 59732370 | 80.3% |
Reaction Steps
An ice-cold solution of 4-(2-furyl)thieno[3,2-d]pyrimidine-2-amine (130 mg, 0.6 mmol) in pyridine (1 mL) was treated with acetyl chloride (47 μL, 0.66 mmol), stirred at room temperature for 16 h, poured into water, extracted with EtOAc, dried (MgSO4) and concentrated in vacuo and purified by chromatography (SiO2:EtOAc:Heptane, 1:1) to give the title compound (125 mg, 80%) as a cream solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384949B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-34c4c51c55d44777a2fcf66afc16e76e |
| Source note | uspto-grants-2008_06 |