Diisobutylaluminumhydride → HCID 59732398, compound

Participants

Reaction Steps

A solution of ethyl 4-(2-furyl)thieno[3,2-d]pyrimidine-2-acetate (0.10 g, 0.35 mmol) in dichloromethane (13 mL) at −75° C. was treated dropwise with di-iso-butylaluminium hydride (0.87 mL, 1.0-M), stirred for 17 h, warmed to ambient temperature and partitioned between Rochelle's salt and dichloromethane. The combined organic phase was dried (MgSO4), concentrated in vacuo and purified by chromatography (SiO2:EtOAc) to give the title compound (21 mg, 25%) as a white solid.

Provenance & Evidence