Cesium carbonate → 4-{4-Nitro-3-[(2-phenoxy-acetyl)-(4-trifluoromethoxy-benzyl)-amino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g (2.19 mmol) 4-[4-nitro-3-(2-phenoxy-acetylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester, 1.07 g (3.29 mmol) cesiumcarbonate and 0.79 g (3.29 mmol) 4-(trifluoromethoxy)benzyl bromide (commercially available) in 6.6 ml DMF was stirred at 110° C. for 2 h. After cooling to room temperature the precipitate was filtered of. The residue was used without further purification. The title compound was isolated as brown solid (0.39 g; 37%). MS(ISP): 631.5 (M+H)+

Provenance & Evidence