HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → 4-[tert-Butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-(2-phenoxy-acetylamino)-benzoic acid allyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | Phenoxyacetic Acid | HCID 19188 | — |
| Reactant | 3-Amino-4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-benzoic acid allylester | HCID 69106851 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[tert-Butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-3-(2-phenoxy-acetylamino)-benzoic acid allyl ester | HCID 68466940 | — |
Reaction Steps
318 mg of phenoxyacetic acid were dissolved in methylenchloride and 0.36 ml of diisopropylcarbodiimide added. 950 mg of 3-amino-4-[tert-butoxycarbonyl-(4-trifluoromethoxy-benzyl)-amino]-benzoic acid allylester were added and the reaction mixture stirred at room temperature for 16 h. The product was extracted from methylenchloride/water without further characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384945B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-8da8319e6c514501ae60adf844824330 |
| Source note | uspto-grants-2008_06 |