HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pentylamine → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid pentylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pentylamine | HCID 8060 | — |
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid | HCID 68463846 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid pentylamide | HCID 68463855 | — |
Reaction Steps
0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of n-pentylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 512.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07384945B2 |
| Source dataset | uspto-grants-2008_06 |
| ORD ID | ord-3f41f35e221e4ed6b9720cc992b5dd58 |
| Source note | uspto-grants-2008_06 |