Ethanol → HCID 69214075, compound

Participants

Reaction Steps

Suspend 2-(5-fluoro-2-nitro-phenylamino)-methyl-thiophene-3-carbonitrile (0.7.9 g, 27 mmol) in ethanol (70 ml), add anhydrous tin(II)chloride(15 g, 79 mmol) in concentrated hydrochloric acid (60 ml) and heat the mixture under reflux for 6 hours. Dilute the mixture with water and allow to cool. Collect the precipitate formed by filtration and dry under high vacuum to give 6-fluoro-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride as a yellow solid (6.5 g, 82%): mass spectrum (FIA) 262 (M+1).

Provenance & Evidence