HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1313240Generated: November 2, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1313240
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Catalyst | 1,3-Di(tricyclo[3.3.1.1~3,7~]decan-1-yl)-1H-imidazol-3-ium tetrafluoroborate | HCID 16218105 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 24.039% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 19.293% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-9a1afcc4876d4c83aa4a6c8a7d85ede4 |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
