HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1313270Generated: October 31, 2026
Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
https://huagongshe.com/reaction/1313270
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Benzene, 1-bromo-4-(trifluoromethyl)- | HCID 67872 | — |
| Reagent | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Catalyst | 1,3-Bis(2,6-di(pentan-3-yl)phenyl)-1H-iMidazol-3-iuM chloride | HCID 92132781 | — |
| Catalyst | HCID 178486303 | HCID 178486303 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | Caffeine | HCID 2519 | — |
| Product | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | 17.71% |
| Product | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | 14.905% |
Provenance & Evidence
| DOI | 10.1021/jacs.6c05959 |
|---|
| Source dataset | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
| ORD ID | ord-96b44766d9e94cdb90c3838c1e87944b |
|---|
| Source note | High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions |
|---|
