反应详情

N-[(1S)-2-(3-Fluorophenyl)-2-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}-1-(benzyloxymethyl)ethyl]-2-methoxyacetamide (15 mg, 0.027 mmol) is dissolved in 10 mL ethanol and Pd (10% on charcoal, 0.29 mg, 0.0027 mmol) is added. The reaction mixture is charged with hydrogen and stirred for 2 h at r.t. After filtration of the reaction mixture via a glass microfibre filter, the solvent evaporated and the residue purified by chromatography (silicagel, eluents: ethylacetate/hexane). 7.5 mg (59.6%) of the title compound as a mixture of stereoisomers are obtained.

1. filtrationAfter filtration of the reaction mixture via a glass microfibre
2. filtrationfilter
3. customthe solvent evaporated
4. customthe residue purified by chromatography (silicagel, eluents: ethylacetate/hexane)
5. addition7.5 mg (59.6%) of the title compound as a mixture of stereoisomers
6. customare obtained