反应详情

Using the method of Example 62, using 3-amino-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione and difluoroacetic acid, stirring overnight at ambient temperature after the addition of the acid, and washing reaction solid with dichloromethane instead of isopropanol: chloroform (3:1) gives the title compound: mass spectrum (APCI, m/e): 270 (M+1); NMR (1H, 300 MHz, DMSO-d6): δ 10.88 (s, 2H), 9.13 (d, 1H, J=6.9 Hz), 7.29-7.13 (m, 4H), 6.49 (t, 1H, 2J(H,F)=53.7 Hz), 4.79 (d, 1H, J=6.9 Hz).

1. additionafter the addition of the acid
2. washwashing
3. customreaction solid with dichloromethane instead of isopropanol: chloroform (3:1)