反应详情

Suspend 2-(4-chloro-2-nitro-phenylamino)-thiophene-3-carbonitrile (4.85 g, 17.35 mmol) in ethanol (40.0 ml). Dissolve tin(II) chloride dihydrate (11.75 g, 52.06 mmol) in 5N HCl (40.0 ml) and then add it to the suspension. Heat the reaction at reflux for 48 hours. Cool the reaction to ambient temperature and then chill it in a refrigerator for 2 hours. Collect the resulting precipitate by vacuum filtration and then dry it under vacuum to give 3.53 g (71%) of the title compound: mass spectrum (ion spray): m/z=250.0 (M+1).

1. temperatureHeat
2. customthe reaction
3. temperatureat reflux for 48 hours
4. temperatureCool
5. customthe reaction to ambient temperature
6. temperaturechill it in a refrigerator for 2 hours
7. customCollect the resulting precipitate
8. filtrationby vacuum filtration
9. customdry it under vacuum