反应详情

温度

50 °C

Dissolve (S)-1,4-dibenzyl-2-(2-methoxy-ethyl)-piperazine (2.0 g, 6.2 mmol) in ethanol (15 mL) in a suitable hydrogenation vessel. Add palladium hydroxide (Pearlman's catalyst, 400 mg), purge vessel with nitrogen, then pressure to 60 psi. Heat to 50° C. and stir vigorously for 18-24 hours. Allow the mixture to cool to ambient temperature. Filter off the catalyst and rinse with ethanol (5 mL). Concentrate in vacuo using a 35° C. bath to afford the title compound (0.81 g, 91.1%). 1H NMR (500 MHz, DMSO-d6) δ 1.41 (m, 2H), 2.12 (t, 1H), 2.43 (td, 1H), 2.53 (m, 2H, 1H), 2.63 (d, 1H), 2.72 (m, 2H), 3.19. (s, 3H), 3.34 (m, 2H).

1. customAdd palladium hydroxide (Pearlman's catalyst, 400 mg), purge vessel with nitrogen
2. temperatureAllow the mixture to cool to ambient temperature
3. filtrationFilter off the catalyst
4. washrinse with ethanol (5 mL)
5. concentrationConcentrate in vacuo
6. customusing a 35° C.