反应详情

2.0 g (20 mmol) of 3-aminomethyl-pyrrolidine are initially introduced into 10 ml of methanol, and 1.8 g (22 mmol) of 97% strength pivalaldehyde are added dropwise at room temperature, after which the internal temperature rises to 30° C. The mixture is subsequently stirred for 1 hour and then concentrated, and the residue is distilled through a Vigreux column.

1. additionare added dropwise at room temperature
2. customrises to 30° C
3. concentrationconcentrated
4. distillationthe residue is distilled through a Vigreux column