Diisopropylethylamine → (S)-10-[3-(2-Methoxy-ethyl)-piperazin-1-yl]-2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene

Participants

Reaction Steps

Add 2-isopropyl-4H-3-thia-4,9-diaza-benzo[f]azulene-10-ylamine hydrochloride (0.32 g, 1.07 mmol) to a solution of (S)-2-(2-methoxy-ethyl)-piperazine (0.31 g, 2.15 mmol) in dimethyl sulfoxide: toluene (1:3, 4 mL). Add diisopropylethylamine (0.19 mL, 1.09 mmol), heat to 110° C. and stir. After an overnight period, cool to ambient temperature to give crude title compound.

Provenance & Evidence