HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 131448Generated: October 25, 2026
(2S)-2-(3-Methoxypropyl)piperazine → (S)-7-fluoro-10-[3-(3-methoxy-propyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene
https://huagongshe.com/reaction/131448
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (2S)-2-(3-Methoxypropyl)piperazine | HCID 45099475 | — |
| Reactant | 7-Fluoro-2-methyl-10H-thieno(2,3-b)(1,5)benzodiazepin-4-amine monohydrochloride | HCID 136192419 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (S)-7-fluoro-10-[3-(3-methoxy-propyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene | HCID 136090382 | 86.3% |
Reaction Steps
Combine 7-fluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride (270 mg, 0.95 mmol), (S)-2-(3-methoxy-propyl)-piperazine (330 mg, 2 mmol) in a mixture of toluene and dimethylsulfoxide (1:2) and stir at 110° C. for 24 hours. Evaporate the mixture then purify by flash chromatography, eluting with a step gradient starting with dichloromethane going to 5% 2N ammonia-methanol in dichloromethane gives (S)-7-fluoro-10-[3-(3-methoxy-propyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene (320 mg, 0.82 mmol): mass spectrum (APCI): m/z=389.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07384934B2 |
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| Source dataset | uspto-grants-2008_06 |
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| ORD ID | ord-f1d1abc1fb1e4e19a4f04631101bdd3d |
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| Source note | uspto-grants-2008_06 |
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