Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 136384344, compound

HRID 131464Notes

Reaction equation

HRID 131464 reaction equation
[ClH:1].Cl.[CH3:3][O:4][CH2:5][CH2:6][C@@H:7]1[NH:12][CH2:11][CH2:10][N:9]([C:13]2[C:22]3[CH:21]=[C:20]([CH3:23])[S:19][C:18]=3[NH:17][C:16]3[CH:24]=[CH:25][CH:26]=[CH:27][C:15]=3[N:14]=2)[CH2:8]1.[C:28]1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[ClH:1].[ClH:1].[CH3:3][O:4][CH2:5][CH2:6][C@@H:7]1[N:12]([CH3:28])[CH2:11][CH2:10][N:9]([C:13]2[C:22]3[CH:21]=[C:20]([CH3:23])[S:19][C:18]=3[NH:17][C:16]3[CH:24]=[CH:25][CH:26]=[CH:27][C:15]=3[N:14]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 136384311HCID 136384311, compound

Product 1

HCID 136384344HCID 136384344, compoundYield 22%

Procedure

In a manner such as that described in Example 269, using (S)-10-[3-(2-methoxyethyl)-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diazabenzo[f]azulene dihydrochloride into the dihydrochloride salt of the title compound (102 mg, 22%): mass Spectrum (ES): m/z 371.2 (M+1 of free base).

Sources & evidence

ORD record
ord-e494022622bd4d7fb2d5851e3ce2b1f7
Source dataset
uspto-grants-2008_06
Patent number
US07384934B2

Reaction notes

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