5-Iodo-1-pyrimidin-2-yl-1H-indazole → 1-Methyl-2-phenyl-2-(1-pyrimidin-2-yl-1H-indazol-5-yloxy)-ethylamine
Reaction equation
[CH3:1][CH:2]([NH2:26])[CH:3]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14]1C=[CH:18][CH:17]=[CH:16][N:15]=1)[N:9]=[CH:8]2.IC1C=C2C(=CC=1)N(C1N=CC=CN=1)[N:32]=C2>>[CH3:1][CH:2]([NH2:26])[CH:3]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[O:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([C:14]1[N:15]=[CH:16][CH:17]=[CH:18][N:32]=1)[N:9]=[CH:8]2Participants
3
Procedure
Prepared as described for 118a using 5-Iodo-1-pyrimidin-2-yl-1H-indazole (120b). Yield 66 mg (20%).
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-4e409723ef42476c8f10364e0683decf
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07728030B2
Reaction notes
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