Acetyl chloride → HCID 136372575, compound

Participants

Reaction Steps

Add a solution of acetyl chloride (0.194 mL, 2.47 mmol) in absolute ethanol to a solution of freebase (S)-2-[2-(2-methoxy-ethyl)-4-(2-trifluoromethyl-4H-3-thia-1,4,9-triaza-benzo[f]azulene-10-yl)-piperazin-1-yl]-ethanol (0.213 g, 0.468 mmol) in absolute ethanol and stir. Isolate the precipitated solid by suction filtration, washing with diethyl ether, and dry the solid at ambient temperature under reduced pressure overnight to give the title compound (0.197 g, 79.8%): mass spectrum (APCI, m/e): 456 (M+1); exact mass spectrum (ES+, m/e, C20H24F3N5O2S.2HCl): calc. 456.1681 (M+1-2HCl), found 456.1668.

Provenance & Evidence