Hydrochloric Acid → HCID 59732477, compound

Participants

Reaction Steps

To a solution of the product 2-[(cyclohexylmethyl)amino]-5-[(2,2-dimethyl-1-oxopropyl)amino]-3-pyridineacetic acid in dry MeOH (7.5 mL) was added 4N HCl solution (in dioxane, 2.5 mL) at 0° C. The reaction mixture was stirred overnight at r.t, and then condensed under vacuum, diluted with AcOEt (50 mL), washed with 1N NH4OH (100 mL), brine (50 mL), and dried over MgSO4. Removal of solvent afforded desired title product (325 mg, 90%). 1H-NMR (CDCl3): δ 0.98 (m, 2H), 1.19 (m, 3H), 1.24 (s, 9H), 1.58 (m, 1H), 1.67 (m, 3H), 1.76 (m, 2H), 3.20 (d, J=6.8 Hz, 2H), 3.39 (s, 2H), 3.63 (s, 3H), 4.98 (brs, 1H), 7.24 (brs, 1H), 7.680 (s, 1H), 7.92 (s, 1H).

Provenance & Evidence