反应详情

37.6 ml cyclohexanone, 5.75 g paraformaldehyde, 38 ml glacial acetic acid and 30.2 g benzylmethylamine hydrochloride were heated at 105° C. (bath temperature) for 25 minutes, while stirring, the mixture was concentrated in vacuo (10 mbar), the residue was taken up in 100 ml 2-butanone and the mixture was concentrated again in vacuo. The residue was heated under reflux with 150 ml 2-butanone. After cooling to room temperature, the mixture was filtered and the residue on the filter was dried in vacuo. 36 g 2-[(benzylmethylamino)methyl]cyclohexanone were obtained.

1. concentrationthe mixture was concentrated in vacuo (10 mbar)
2. concentrationthe mixture was concentrated again in vacuo
3. temperatureThe residue was heated
4. temperatureunder reflux with 150 ml 2-butanone
5. filtrationthe mixture was filtered
6. customthe residue on the filter was dried in vacuo