反应详情

温度

60 °C

5.00 g tetrahydrothiopyran-4-one were dissolved in 15 ml acetonitrile, and 4.03 g N,N-dimethyl-methylenammonium chloride, followed by 40 μl acetyl chloride, were added. After the mixture had been stirred at a bath temperature of 60° C. for 45 minutes, it was stirred at room temperature for 60 hours and the precipitate formed was filtered off with suction and dried. 8.17 g 3-dimethylaminomethyl-tetrahydrothiopyran-4-one hydrochloride with a melting point of 155-157° C. were obtained. The corresponding base was liberated from this with methylene chloride and sodium hydroxide solution (32 percent strength by weight).

1. additionwere added
2. stirringit was stirred at room temperature for 60 hours
3. customthe precipitate formed
4. filtrationwas filtered off with suction
5. customdried