Imidazole → HCID 69214867, compound

Participants

Reaction Steps

To a solution of the product of step b) (1.2 g) and imidazole (0.24 g) in dichloromethane (20 ml) was added tert-butyldimethylsilyl chloride (0.54 g). After stirring at ambient temperature for 16 h the mixture was washed with water and the organics poured onto a biotage column. Gradient elution with 0 to 5% methanol in dichloromethane gave the sub-title compound as a colourless solid (1.55 g). δ 1HCDCl3 0.09 (3H,s), 0.11 (3H,s), 0.90 (9H,s), 0.99 (6H,d), 2.30 (1H,non), 2.44 (3H,s), 3.36 (3H,s), 3.54 (1H,dd), 3.64 (1H,dd), 3.75 (1H,d), 3.84 (1H,dd), 3.98 (1H,dd), 4.47 (1H,dd), 4.89 (1H,dd).

Provenance & Evidence