Dimethylformamide → 1,2,3,4-Tetrahydro-6-[2-(hydroxymethyl)-1H-benzimidazol-1-ylmethyl]-3-methyl-1-(isobutyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxylic acid, methyl ester

関与物質

役割	名称	HCID	仕込み量
反応物	Dimethylformamide	HCID 6228	—
反応物	Potassium Carbonate	HCID 11430	—
反応物	2-(Hydroxymethyl)-1H-benzimidazole	HCID 78569	—
反応物	6-[(4,5-Dichloro-2-methyl-1H-imidazol-1-yl)methyl]-5-[4-(S)-hydroxy-2-isoxazolidinylcarbonyl]-3-methyl-1-(isobutyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione	HCID 10142559	—
生成物	1,2,3,4-Tetrahydro-6-[2-(hydroxymethyl)-1H-benzimidazol-1-ylmethyl]-3-methyl-1-(isobutyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxylic acid, methyl ester	HCID 86760682	—

反応手順

The product of example 3 part b) (0.6 g,) was dissolved in DMF (5 ml). 2-Hydroxymethyl-benzimidazole (0.28 g,) and anhydrous potassium carbonate (0.6 g) were added to the solution, which was stirred for 16 h. The sub-title compound was obtained as a white solid after filtration of the reaction mixture and evaporation (0.18 g). MS (APCI) 457 [M+H]+. δ 1HCDCl3 0.87 (3H,s), 0.9 (3H,s), 2.1-2.2 (m, 1H), 3.38 (s,3H), 3.57-3.64 (m,3H), 3.96 (s,3H), 4.97 (s,2H), 5.64 (s,2H), 7.26-7.38 (m,2H), 7.22-7.3 (m,1H) and 7.74-7.8 (m,1H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07384950B2
出典データセット	uspto-grants-2008_06
ORD ID	ord-8ce2a44baf4c4238a7f1a5e25c79a9f7
出典メモ	uspto-grants-2008_06