1H-Pyrrolo(2,3-b)pyridine → (s)-5-[4-Hydroxyisoxazolidin-2-ylcarbonyl]-3-methyl-1(isobutyl)-6-(1h-pyrrolo[2,3-b]pyridin-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4(1h,3h)-dione

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1H-Pyrrolo(2,3-b)pyridine	HCID 9222	—
Edukt	6-[(4,5-Dichloro-2-methyl-1H-imidazol-1-yl)methyl]-5-[4-(S)-hydroxy-2-isoxazolidinylcarbonyl]-3-methyl-1-(isobutyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione	HCID 10142559	—
Produkt	(s)-5-[4-Hydroxyisoxazolidin-2-ylcarbonyl]-3-methyl-1(isobutyl)-6-(1h-pyrrolo[2,3-b]pyridin-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4(1h,3h)-dione	HCID 10116874	—

Reaktionsschritte

The subtitle compound was prepared using the procedure described in example 3 part c) from the product of example 3 part b) and 7-azaindole. MS (APCI) 427 [M+H]+. δ 1HCDCl3 0.85 (3H,s), 0.92 (3H,s), 2.15-2.25 (1H,m), 3.38 (3H,s), 3.66 (3H,d), 4.03 (3H,s), 4.97 (s,2H), 5.61 (2H,s), 6.49-6.91 (1H,d), 7.06-7.14 (1H,m), 7.38 (1H,d), 7.91 -7.95 (1H,m) and 8.31-8.37 (1H, m).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07384950B2
Quelldatensatz	uspto-grants-2008_06
ORD ID	ord-8178a515bb634223b6e6c6f840546816
Quellennotiz	uspto-grants-2008_06