Ethyl Acetate → 1,2,3,4-Tetrahydro-3-methyl-6-[2-(methylamino)-1H-benzimidazol-1-ylmethyl]-1-(isopropyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxylic acid, methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Ethyl Acetate	HCID 8857	—
Reactant	N-Methyl-1H-benzo[d]imidazol-2-amine	HCID 676520	—
Reactant	5-[[4-Hydroxyisoxazolidin-2-yl]carbonyl]-3-methyl-1-(1-methylethyl)-6-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione	HCID 68804515	—
Product	1,2,3,4-Tetrahydro-3-methyl-6-[2-(methylamino)-1H-benzimidazol-1-ylmethyl]-1-(isopropyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxylic acid, methyl ester	HCID 86760684	—

Reaction Steps

Prepared using the procedure described in example 13 vii) part a) from the product of example 8 part c) and 2-methylaminobenzimidazole to give the sub-title compound after trituration with ethyl acetate followed by filtration. MS(ESI) 442 [M+H]+. δ 1HDMSO 1.40-1.42 (6H,d), 2.94-2.96 (3H,d), 3.16 (3H,s), 3.85 (3H,s), 4.3 (1H, bs), 5.39 (2H,s), 6.84-6.99 (3H,m), 7.11-7.14 (1H, d), 7.20-7.22 (1H, d)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07384950B2
Source dataset	uspto-grants-2008_06
ORD ID	ord-9f36bb20396c4a0081799859323dbfc8
Source note	uspto-grants-2008_06