(1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine → (1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

HRID 13160Notes

Reaction equation

HRID 13160 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11](I)=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N1C2C(=CC([O:28][C@H:29]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C@@H:30]([NH2:32])[CH3:31])=CC=2)C=N1)(C)C>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11]([O:28][C@H:29]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[C@@H:30]([NH2:32])[CH3:31])=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 59339639(1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amineHCID 593397901-cyclopentyl-5-iodo-1H-indazole

Product 1

HCID 59339798(1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

Procedure

Prepared from 1-cyclopentyl-5-iodo-1H-indazole (130c, 158 mg, 500 μmol) as described for 129b. Yield 34 mg (20%).

Sources & evidence

ORD record
ord-25a4644d359d4a9199423de00749c2be
Source dataset
uspto-grants-2010_06
Patent number
US07728030B2

Reaction notes

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