Potassium Hydroxide → HCID 11397968, compound

HRID 131608Notes

Reaction equation

HRID 131608 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:36])[C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:18]3[CH:20]=[C:21]([NH:24][C:25]([NH:27][CH2:28][C:29]([O:31]CC)=[O:30])=[O:26])[CH:22]=[CH:23][C:17]=3[O:16][C:15]=2[C:14]([O:34][CH3:35])=[CH:13][CH:12]=1)=[O:10].[OH-].[K+]>O.CO>[Cl:36][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:18]3[CH:20]=[C:21]([NH:24][C:25]([NH:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])[CH:22]=[CH:23][C:17]=3[O:16][C:15]=2[C:14]([O:34][CH3:35])=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 11752924HCID 11752924, compound

Product 1

HCID 11397968HCID 11397968, compoundYield 35.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N-(3,5-dichloropyrid-4-yl)-4-methoxy-8-(2-ethoxy-2-oxo-ethylamino carbonylamino)-dibenzo[b,d]furan-1-carboxamide (Example 50) (150 mg, 0.28 mmol) was hydrolysed using potassium hydroxide (2 eq.) in 3 ml water and 3 ml methanol for 30 min. at room temperature. The solid precipitated was filtered and washed with methanol to obtain the product as white solid (50 mg).mp: >250° C.

Workup

  1. customfor 30 min.
  2. customat room temperature
  3. customThe solid precipitated
  4. filtrationwas filtered
  5. washwashed with methanol

Sources & evidence

ORD record
ord-6b976192e726459bb80f5a04a730ea7a
Source dataset
uspto-grants-2008_06
Patent number
US07384962B2

Reaction notes

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