反应详情

To a degassed suspension of 4-formylphenylboronic acid (100 mg), 2-bromopyrimidine (107 mg) and sodium carbonate (212 mg) in acetonitrile (2 ml)/water (2 ml) was added freshly prepared tetrakis(triphenylphosphine)palladium(0), (40 mg) and the mixture was refluxed under nitrogen, for 20 hrs. The cooled reaction mixture was diluted with water and extracted with ethyl acetate (×2). The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography over silica, eluting with iso-hexane/ethyl acetate (75:25) to afford the sub-title compound as a solid (90 mg).

1. temperaturethe mixture was refluxed under nitrogen, for 20 hrs
2. customThe cooled reaction mixture
3. extractionextracted with ethyl acetate (×2)
4. dry with materialThe combined organic extracts were dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customThe residue was purified by column chromatography over silica
8. washeluting with iso-hexane/ethyl acetate (75:25)