3,5-Dimethyl-1,2-thiazole-4-carbaldehyde → 6-[(3,5-Dimethyl-4-isothiazolyl)hydroxymethyl]-1,2,3,4-tetrahydro-3-methyl-1-(1-methylethyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

HRID 131632Notes

Reaction equation

HRID 131632 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:13](=[O:15])[N:12]([CH3:16])[C:11](=[O:17])[N:10]([CH:18]([CH3:20])[CH3:19])[C:9]=2[S:8][CH:7]=1)=[O:5])[CH3:2].[CH3:21][C:22]1[C:26]([CH:27]=[O:28])=[C:25]([CH3:29])[S:24][N:23]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:13](=[O:15])[N:12]([CH3:16])[C:11](=[O:17])[N:10]([CH:18]([CH3:19])[CH3:20])[C:9]=2[S:8][C:7]=1[CH:27]([C:26]1[C:22]([CH3:21])=[N:23][S:24][C:25]=1[CH3:29])[OH:28])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 138427513,5-Dimethyl-1,2-thiazole-4-carbaldehydeHCID 16102858Ethyl 1-isopropyl-3-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate

Product 1

HCID 693138406-[(3,5-Dimethyl-4-isothiazolyl)hydroxymethyl]-1,2,3,4-tetrahydro-3-methyl-1-(1-methylethyl)-2,4-dioxo-thieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Procedure

Prepared by the method of example 15 part a) using 1,2,3,4-tetrahydro-3-methyl-1-(1-methylethyl)-2,4-dioxothieno[2,3-d]pyrimidine-5-carboxylic acid ethyl ester, and 3,5-dimethyl-4-isothiazolecarboxaldehyde.

Workup

  1. customPrepared by the method of example 15 part a)

Sources & evidence

ORD record
ord-42c867ccf0ef41fd8856cbb9b3880984
Source dataset
uspto-grants-2008_06
Patent number
US07384951B2

Reaction notes

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