Thionyl Chloride → HCID 23117346, compound

HRID 131644Notes

Reaction equation

HRID 131644 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[CH:7]=[C:8]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)[CH:9]=[CH:10][C:11]=1[CH3:12]>C(Cl)(Cl)Cl>[CH3:5][C:6]1[CH:7]=[C:8]([CH2:13][CH2:14][CH2:15][C:16]([Cl:3])=[O:18])[CH:9]=[CH:10][C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 2319924-(3,4-dimethylphenyl)butanoic acid

Product 1

HCID 23117346HCID 23117346, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2.5 mL of thionyl chloride was added at room temperature to a 60 mL chloroform solution of 3.3 g of compound 1-1 obtained in Reference Example 1, and the system was refluxed under heating, for 10 hours. After the reaction, reduced-pressure solvent distillation was performed to obtain 4-(3,4-dimethylphenyl)butanoyl chloride.

Workup

  1. customobtained in Reference Example 1
  2. temperaturethe system was refluxed
  3. temperatureunder heating, for 10 hours
  4. customAfter the reaction, reduced-pressure solvent distillation

Sources & evidence

ORD record
ord-44022c48ce3246c4873f0e7fa3ca2194
Source dataset
uspto-grants-2008_06
Patent number
US07384974B2

Reaction notes

Loading…