Dimethylformamide → HCID 23117348, compound

Participants

Reaction Conditions

Reaction Steps

0.46 mL of butyl iodide and 0.83 g of potassium carbonate were added to a 10 mL dimethylformamide solution of 0.5 g of the compound obtained in Example 39, and the system was stirred for 2 hours at 80° C. After the reaction, water was added and extraction was performed with ethyl acetate. The extracted organic layer was washed with saturated brine, dried with magnesium sulfate, and then subjected to reduced-pressure solvent distillation. The residue thus obtained was refined by silica gel column chromatography (10% ethyl acetate/hexane) and then recrystallized with ethanol to obtain 0.48 g of 2-acetyl-4,5-dihydro-7-(n-butyloxy)naphtho[1,2-b]thiophene (Table 7-1) in the form of yellow crystals.

Provenance & Evidence