4-Methoxycarbonylphenylboronic acid → HCID 69220556, compound

HRID 131662Notes

Reaction equation

HRID 131662 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]([CH3:14])=[N:12][N:13]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:15][O:16][C:17]([C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1)=[O:18]>>[CH3:15][O:16][C:17]([C:19]1[CH:24]=[CH:23][C:22]([C:2]2[CH:3]=[C:4]([C:9]3[O:10][C:11]([CH3:14])=[N:12][N:13]=3)[CH:5]=[CH:6][C:7]=2[CH3:8])=[CH:21][CH:20]=1)=[O:18].[CH3:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]2[O:10][C:11]([CH3:14])=[N:12][N:13]=2)=[CH:3][C:2]=1[C:22]1[CH:23]=[CH:24][C:19]([C:17]([O:16][CH3:15])=[O:18])=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 114707752-(3-Bromo-4-methylphenyl)-5-methyl-1,3,4-oxadiazole

Product 1

HCID 69220556HCID 69220556, compound

Procedure

Methyl 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylate Methyl 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylate was prepared from 2-(3-bromo-4-methylphenyl)-5-methyl-1,3,4-oxadiazole and [4-(methoxycarbonyl)phenyl]boronic acid using method D. NMR; δH CDCl3 8.12,(2H, d), 7.94, (1H, dd), 7.90,(1H, d), 7.43,(3H, m), 3.96,(3H, s), 2.61,(3H, s), 2.33,(3H, s). LCMS; retention time 3.37 min, MH+ 309.

Sources & evidence

ORD record
ord-a3083ce2fe974a8892d16678681ddc0c
Source dataset
uspto-grants-2008_06
Patent number
US07384963B2

Reaction notes

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