4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid → 2'-Methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carbonyl chloride

Participants

Reaction Steps

2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carbonyl chloride Oxalyl chloride (0.073 ml, 0.82 mmol) was added to a suspension of 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid (200 mg, 0.68 mmol), and DMF (2 drops) in DCM (10 ml) at 0° C. The reaction was stirred at room temperature for 1.5 h and the solvents evaporated under vacuum to give 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carbonyl chloride as a white solid (0.212 g, 100%). NMR; δH [2H6]—DMSO 8.03,(2H, d), 7.90,(1H, dd), 7.76,(1H, d), 7.56-7.53,(3H, m), 2.56,(3H, s), 2.30,(3H, s).

Provenance & Evidence