反应详情

N-(2-Methoxy-5-nitrobenzyl)acetamide 2-Acetamidomethyl-4-nitrophenol (2 g), sodium carbonate (2 g) and iodomethane (2 ml) were stirred in acetone (30 ml) at reflux 4 h. The mixture was filtered, the filtrate evaporated to dryness. The residue was warmed with aqueous sodium carbonate, washed with water and dried. Crystallised from ethanol/dilute acetic acid to give N-(2-methoxy-5-nitrobenzyl)acetamide as buff prisms. MP: 158.5-159.5° C.

1. temperatureat reflux 4 h
2. filtrationThe mixture was filtered
3. customthe filtrate evaporated to dryness
4. temperatureThe residue was warmed with aqueous sodium carbonate
5. washwashed with water
6. customdried
7. customCrystallised from ethanol/dilute acetic acid