Phenyl isocyanate → HCID 47448403, compound

Participants

Reaction Steps

N-(3-Nitrobenzyl)-N′-phenylurea 3-Nitrobenzylamine hydrochloride (377 mg, 2.0 mmol) and triethylamine (278 μl, 2 mmol) were stirred in ethanol (5 ml) for 15 min. Phenylisocyanate (230 μl, 2.12 mmol) was added dropwise to the solution and stirring continued for 45 min at room temperature once the addition was complete. The reaction was concentrated under vacuum and the residue partitioned between ethyl acetate and water. The organic phase was washed with water, dried (sodium sulphate) and the solvent evaporated under vacuum to give N-(3-nitrobenzyl)-N′-phenylurea (520 mg). MP; 153-156° C.

Provenance & Evidence