Ethyl isocyanate → HCID 47448393, compound

Participants

Reaction Steps

N-Ethyl-N′-(3-nitrobenzyl)urea 3-Nitrobenzylamine hydrochloride (754 mg, 4.0 mmol) and triethylamine (404 mg, 4 mmol) were stirred in THF (10 ml) for 15 min in an ice bath. Ethylisocyanate (335 μl, 4.23 mmol) was added dropwise to the solution and the reaction allowed to stand at room temperature for 2 h after addition was complete. The reaction was partitioned between ethyl acetate (30 ml) and water (30 ml). The organic phase was washed with water, brine and dried (sodium sulphate). The solvent was evaporated under vacuum to give N-ethyl-N′-(3-nitrobenzyl)urea (880 mg). Rf; DCM/methanol (10:1) 0.40.

Provenance & Evidence